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Sèvis modifikasyon peptides

Modifikasyon peptide chanje pwopriyete fizik ak chimik nan peptide a pa modifye chèn prensipal la ak estrikti chèn bò nan peptide a, kidonk amelyore byodisponibilite li yo. Dwòg peptide modifye yo ka siyifikativman diminye iminojenisite, diminye efè toksik, ogmante solubilite dlo, pwolonje tan aksyon an nan kò a, chanje distribisyon an nan kò a, elatriye. Modifikasyon peptide komen yo enkli: modifikasyon fen C, modifikasyon N tèminal, modifikasyon rezidi entèmedyè, ak modifikasyon sikilasyon.

 

 

N fin modifikasyon

•Ac •Alyl •Kolesteril- •N-Propargylglycine-
•Fmoc • Acryl •Fruktoz- •Ad
•CBZ •Allok •Gloz- •BPS-
•Boc •Pyr •DMAP-Ac •Mofòlin-4-karbonil-
•Bz •D-Pyr •NTriAc •Trans-Cinamoyl
•Bz (5-NH2,2-NO2) •LA- • PhAc •2-Furoyl
•Bz (4-F) •Mpa- •Py-Ac •Methacryl-
•Bz (4-NO2) •Tos •N-Amidinoglizin •BPA-

 

C fin modifikasyon

•-pNA •-OM •-ONP •-OSu
•-NH2 •-OEt •-AMC •-NHMe
•-ol •-OBzl •-AFC •-NHEt

 

Asidifikasyon gra

•Pou

•MeOSuc

•5-Hexynoic asid

•F-Lau-

•MeOCO

•Iba

•Heptanedioic asid

• Myr-

•2-Br-Ac

• asid pentenoik

•Oktòb-

•F-Mon-

•2-Cl-Ac

•pentinoyl

•F-Oktòb-

•Pentadekonil-

•2-I-Ac

•Hex-

•Desanm-

•Pami-

•OH-Ak

•5-heptenoic asid

•Asid sebasik

• Cys (Pal)

•3-Bromopropionyl

•Trans-3-hexenoyl-

•F-Desanm-

•Pam3C-

•Men-

•Linoletik-

•Undecyl-

•Ste-

•Suk

•10,12-Pentacosadiynoic asid

•Lau-

•Oktandioik asid

 

Metilasyon

• Lys (mwen) •Arg (mwen) • Tyr (mwen) • Tyr (Et)
•Lys (Me2) •Arg (Me2) asimetri • Thr (mwen) •D-Tyr (Et)
•Lys (Me3) •Arg (Me2) simetrik •Ser (mwen)  

 

Fosforilasyon

•pSer •D-pSer •Di-sit yo an sekans •4-sit nan sekans
•pTyr •D-pTyr •Tri-sit yo an sekans •5-sit nan sekans
•pThr •D-pThr    

 

Branch peptide

•Simetrik 2 Branch yo •Simetrik 4 Branch yo •Simetrik 8 Branch yo •Lys simetrik 2 Branch
•Lys simetrik 4 Branch •Lys simetrik 8 Branch •Orn simetrik 2 Branch •Orn simetrik 4 Branch
•Orn simetrik 8 Branch •Glu 2 Branch (pi) •Glycerol 3 Branch ester • Thr (Peptide2)
•Ser (Peptide2) • Lys (Peptide2)    

 

Peptid siklik

•Mono disulfid pon •Doub disulfide pon •Triple disulfide pon •Random Triple Disulfide pon
•Amide Cyclic (chèn bò) pa Lys •Amide Cyclic (chèn bò) pa Orn •Oksidasyon ant Se-Cys

• Amid Cyclic (fen)
•Menm Sekans Inter-pon disulfid pa oksidasyon Cys •Sekans diferan Inter-pon disulfid pa oksidasyon Cys

 

Etikèt fluoresans / lank

•Biotin-

•FITC-

•Dansyl-

•Lys (Dnp)

•DeThioBiotin

•-ED-FITC

•-EDDansyl

•D-Lys (Dnp)

•-EDBiotin

•-Lys (FITC)-

•-Lys (Dansyl)-

•Dab (Dnp)

•Glu (Biotin-PEG2)

•-Lys (FITC)

•-Lys (Dansyl)

•Dap (Dnp)

•-Lys (Biotin)-

•Lys (Ahx-FITC)

•Dansli-e-Lys

•-EDDnp

•-Lys (Biotin)

•FITC-e-Lys

•Dansyl-Ahx-

•-Lys (LC-Biotin)-

•FITC-Ahx-

•5-FAM-

•-Lys (LC-Biotin)

•5-TAMRA-

•5,6-FAM

•Biotin-e-Lys

•5 (6)-TAMTA-

•6'FAM

•Lys (S-S-Biotin)

•-EDYAMRA

•-ED-5-FAM

•Biotin-Ahx-

•-Lys (TAMRA)-

•-Lys (5-FAM)-

•Orn (Biyo)

•-Lys (5-TAMRA)

•Lys (5,6-FAM)

•MCA-

•5-TAMRA-e-Lys

•-Lys (5-FAM)

•-Lys (MCA)-

•5-TAMRA-Acp

•5-FAM-E-Lys

•-Lys (MCA)

•5-FAM-Ahx-

•Lys (MCA)-

    

 

BSA, KLH, OVA kouple

• BSA-Peptide N tèminal •KLH-Peptide N tèminal •OVA-Peptide N tèminal • BSA-Peptide C tèminal
•KLH-Peptide C tèminal •OVA-Peptide C tèminal •BSA-Peptide atravè Cys •KLH-Peptide atravè Cys
•OVA-Peptide atravè Cys      

 

Phe & Tyr dérivés

•D-2-Cl-Phe

•D-4-F-Phe

•L-2-Me-Phe

•L-3-I-Tyr

•L-2-Cl-Phe

•L-4-F-Phe

•D-4-Me-Phe

•D-3,5-DiI-Tyr

•D-3-Cl-Phe

•D-4-NO2-Phe

•L-4-Me-Phe

•L-3,5-DiI-Tyr

•L-3-Cl-Phe

•L-4-NO2-Phe

•D-4-NH2-Phe

•D-3-NO2-Tyr

•D-4-Cl-Phe

•D-4-I-Phe

•L-4-NH2-Phe

•L-3-NO2-Tyr

•L-4-Cl-Phe

•L-4-I-Phe

•D-3-Cl-Tyr

•D-3,5-DiNO2-Tyr

•D-3,4-DiCl-Phe

•D-3-CN-Phe

•L-3-Cl-Tyr

•L-3,5-DiNO2-Tyr

•L-3,4-DiCl-Phe

•L-3-CN-Phe

•D-3,5-DiCl-Tyr

•L-3-F-Tyr

•D-4-Br-Phe

•D-4-CN-Phe

•L-3,5-DiCl-Tyr

•L-4-NO2-Phg

•L-4-Br-Phe

•L-4-CN-Phe

•D-3,5-DiBr-Tyr

•D-4-NO2-Phg

•D-3-F-Phe

•D-2-Me-Phe

•L-3,5-DiBr-Tyr

•L-3,5-DiF-Phe

•L-3-F-Phe

•D-3-I-Tyr

    

 

Linker

•Gly •Ava •AEA •GABA
•Beta-Ala • Ahx •Ado •Mini-PEG
•Mini-PEG2 •Mini-PEG3 •PEG4  

 

Rezin

•peptide sou Wang résine •peptide sou résine 2-CTC •peptide sou Rink Amide AM Resin •peptide sou Rink Amide MBHA Resin

 

D asid amine

•D-Ala •D-Lys •D-Glu •D-Tyr
•D-Arg •D-Met •D-Gln •D-Thr
•D-Asp •D-Pro •D-Li •D-Trp
•D-Asn •D-Phe •D-Leu •D-Val
•D-Cys •D-Sèr    

 

Omotip asid amine

•Har

•HomoCit

•beta-HomoMet

•beta-HomoSer

•D-Har

•D-HomoCit

•beta-HomoPro

•beta-HomoThr

•Hcy

•HomoLeu

•beta-HomoVal

•beta-HomoTrp

•HPh

•HomoPro

•beta-HomoAsp

•beta-HomoTyr

•D-HPh

•D-HomoPro

•beta-HomoAsn

• Azidohomoalanine

•Hse

•beta-HomoIle

•beta-HomoGlu

•beta-HomoAla

•D-Hse

•beta-HomoLeu

•beta-HomoGln

•beta-HomoPhe

 

Asid amine espesyal

•beta-Asp

•3-Thi

•D-Chg

• Cys (pMeBzl)

•D-beta-Asp

•Aib

•Ac6c

• Cys (pMeOBzl)

•gamma-Glu

•Abu

•Dab

•Oic

•D- gama-Glu

•D-Abu

•Dap

•Tic

• Cys (Cam)

•Hyp

•Pra

•D-Tic

•D-Cys (Cam)

•Phg

•D-Pra

• Cys (Bzl)

• Cys (Acm)

•D-Phg

•Allo-Thr

•Epsilon-Lys

• Cys (tBu)

•Nva

•D-Allo-Thr

•D-Epsilon-Lys

• Cys (StBu)

•D-Nva

•Gly (allyl)

•5-ASA

•Met (O)

•Nle

•D-Gly (allyl)

•Bpa

•D-Met (O)

•D-Nle

• Cys (Pyrene-maleimid)

•Pip

• Cys (SNO)

•Cit

•D-1-Nal

•Nip

•Met (O)2

•D-Cit

•L-1-Nal

•2-Aze

•D-Met (O)2

•Orn

•D-2-Nal

•3-Aze

•Lys (Ac)

•D-Orn

•L-2-Nal

•[Psi (CH2NH)]

•Ac-Lys

• Plim

•D-2-Pal

•[CS-NH]

•Lys (Dde)

•D-Pen

•L-2-Pal

•Se-Met

•Tle

•Cpg

•D-3-Pal

•Se-Cys

•Ser (asid oktanoik)

•Cha

•L-3-pal

•DOPA

•Ser (asid lipoik)

•D-Cha

•D-4-Pal

• isoGln

•D-Ser (asid oktanoik)

• Chg

•L-4-Pal

•D-isoGln

•Arg (Boc2)

•Asp-OMe

•D-Glu (OtBu)

• Lys (Z)

•Arg (NO2)

•Asp-OtBu

•Gln (Trt)

•Ser (Bzl)

•Arg (Z2)

•Asn (Trt)

•Li (Boc)

•Ser (Trt)

•Arg (pbf)

• Cys (MMt)

•Li (Trt)

•Ser (tBu)

•D-Arg (pdf)

• Cys (Trt)

• Tyr (propargyl)

• Tyr (tBu)

• Asp (Oall)

•D-Cys (Trt)

• Lys (Boc)

• Asp (OBn)

•Glu (Oall)

• Lys (DMT)

•D-Tyr (tBu)

• Asp (OBzl)

•Glu (OBzl)

•Lys (Fomc)

• Thr (tBu)

• Asp (OMe)

•Glu (OMe)

• Lys (Mtt)

•Trp (Boc)

• Asp (OtBu)

•Glu (OtBu)

•Lys (Trt)

•Trp (Farnesyl)

  

 

Avi:

1. Enfòmasyon ki pi wo yo se pou referans sèlman, epi yo pral soumèt kondisyon modifikasyon peptide Customized ou a nan laboratwa a pou evalyasyon.

2. Si ou gen nenpòt kondisyon modifikasyon peptide ki pa nan lis nan tablo a, ou ka kontakte nou dirèkteman pou konsiltasyon.

 

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